Acadesine Aicar Sarms Powder CAS 2627-69-2

Product DescriptionAcadesine (INN), also known as  5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, AICA-riboside,and AICAR, is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.

Function

Acadesine acts as an AMP-activated protein kinase. It stimulates glucose uptake and increases the activity of p38 mitogen-activated protein kinases α and β in skeletal muscle tissue, as well as suppressing apoptosis by reducing production of reactive oxygen compounds inside the cell.

In 2008, researchers at the Salk Institute discovered that acadesine injected in mice significantly improved their performance in endurance-type exercise, apparently by converting fast-twitch muscle fibers to the more energy-efficient, fat-burning, slow-twitch type. They also looked at the administration of GW 501516 (also called GW1516) in combination with acadesine. Given to mice that did not exercise, this combination activated 40% of the genes that were turned on when mice were given GW1516 and made to exercise. This result drew attention to the compound as a possible athletic endurance aid.

Specification

Item	Specification	Result
Appearance	White powder	Complies
Related substance (HPLC)	Total impurity ≤0.5% Max single impurity ≤0.1%	0.2% 0.06%
Odor	Characteristic	Complies
Assay	99%	99.8%
Sieve analysis	100% pass 80 mesh	Complies
Loss on Drying Residue on Ignition	≤1.0% ≤1.0%	0.12% 0.09%
Heavy Metal	<10ppm	Complies
As	<0.1ppm	0.05ppm
Pb	<0.1ppm	0.05ppm
Cd	<0.1ppm	0.05ppm
Residual Solvents	<100ppm	Complies
Residual Pesticide	Negative	Complies
Microbiology
Total Plate Count	<1000cfu/g	Complies
Yeast & Mold	<100cfu/g	Complies
E.Coli	Negative	Complies
Salmonella	Negative	Complies